Rossi Elisa

MCF, UPD

Research theme : Theme 1

Phone: 01 70 64 74 21

Biography

Senior Lecturer – Unit of Haematology and Inserm UMR-S 1140, Faculty of Pharmacy of Paris, Paris Descartes University.

After an Internship in Clinical Pathology (2000-2005) at the Hospital “Spedali Civili di Brescia”, Italy and a Doctorate in Pathology and Medical Genetics (2006-2009), Faculty of Medicine, University of Pavia, Pavia, Italy, Dr. Rossi has developed a wide experience in research as a postdoctoral researcher (2010-2016) at the “Consejo Superior de Investigacion Cientifica – CSIC” in Madrid, Spain, at the “Harvard Medical School – Children’s Hospital”, Boston EEUU, at the University of Salamanca, Salamanca, Spain, to finally join the unit Inserm UMRS1140 – Innovative Therapies in Haemostasis, Faculty of Pharmacy – Paris Descartes University. Thanks to her background in pathology and angiogenesis she joined the group of Pr. David Smadja to develop a new research project linking the cellular aspect of the vessel formation/functions and haemostasis. Currently she is studying the functions of a membrane glycoprotein (endoglin, alias CD105) in the endothelial cell-forming colony (ECFC) as well as in primary haemostasis.

Author of more than 55 publications in PubMed, she had the opportunity to supervise M1, M2 and PhD students in different countries and languages, and to present her results in many international congresses. Recently she received an award at the HHT International Scientific Conference (2017).

Latests Major Publications

Rossi E, Chassac-Poirault S, Lokajckyk A , Bourdoncle P, Dizier B, Bacha N, Gendron N, Blandinieres A, Guerin CL, Gaussem P, Smadja DM, Human endothelial colony forming cells express 1 intracellular CD133 that modulates theirvasculogenic properties. Stem Cell Rev.2019 : sous presse

Rossi E, Pericacho M, Bachelot-Loza C, Pidard D, Gaussem P, Poirault-Chassac S, Blanco FJ, Langa C, González-Manchón C, Novoa JML, Smadja DM, Bernabeu C. Human endoglin as a potential new partner involved in platelet-endothelium interactions. Cell Mol Life Sci. 2018 ; 75(7):1269-1284.

Rossi E, Smadja D, Goyard C, Cras A, Dizier B, Bacha N, Lokajczyk A, Guerin CL, Gendron N, Planquette B, Mignon V, Bernabéu C, Sanchez O, Smadja DM. Co-injection of mesenchymal stem cells with endothelial progenitor cells accelerates muscle recovery in hind limb ischemia through an endoglin-dependent mechanism. Thromb Haemostas. 2017 ;117(10):1908-1918.

Rossi E, Smadja DM, Boscolo E, Langa C, Arevalo MA, Pericacho M, Gamella L, Kauskot A, Botella LM, Gaussem P, Bischoff J, Lopez-Novoa JM, Bernabeu C. Endoglin regulates mural cell adhesion in the circulatory system. Cell Mol Life Sci 2016 ;73(8):1715-39.

Rossi E, Sanz-Rodriguez F, Eleno N, Duwell A, Blanco FJ, Langa C, Botella LM, Cabañas C, Lopez-Novoa JM, Bernabeu C. Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration. Blood 2013; 121 (2): 403-415.

Major publications 2020 / 2010

Rossi E, Chassac-Poirault S, Lokajckyk A , Bourdoncle P, Dizier B, Bacha N, Gendron N, Blandinieres A, Guerin CL, Gaussem P, Smadja DM, Human endothelial colony forming cells express 1 intracellular CD133 that modulates their vasculogenic properties. Stem Cell Rev. 2019 Mar 16. doi: 10.1007/s12015-019-09881-8. IF : 4.7 (Q2)

Luo H, Rossi E, Saubamea B, Chasseigneaux S, Cochois V, Choublier N, Smirnova M, Glacial F, Perrière N, Bourdoulous S, Smadja D, Menet MC, Couraud PO, Cisternino S, Decleves X. Cannabidiol increases proliferation, migration, tubulogenesis and integrity of human brain endothelial cells through TRPV2 activation. Mol Pharm. 2019 Mar 4;16(3):1312-1326. doi: 10.1021/acs.molpharmaceut.8b01252. IF: 4.556 (Q1).

Rossi E, Bernabeu C, Smadja DM. Endoglin as an Adhesion Molecule in Mature and Progenitor Endothelial Cells: A Function Beyond TGF-β. Front Med (Lausanne). 2019 Jan 30;6:10. doi: 10.3389/fmed.2019.00010. eCollection 2019. Review.

Blandinières A, Gendron N, Bacha N, Bièche I, Chocron R, Nunes H, Nevo N, Rossi E, Crestani B, Lecourt S, Chevret S, Lokajczyk A, Mignon V, Kisaoglu A, Juvin K, Bertil S, Valeyre D, Cras A, Gaussem P, Israël-Biet D, Smadja DM. Interleukin-8 release by endothelial colony-forming cells isolated from idiopathic pulmonary fibrosis patients might contribute to their pathogenicity. 2019 Jan 3. doi: 10.1007/s10456-018-09659-5. IF: 4.35 (Q2)

Bacha NC, Blandinieres A, Rossi E, Gendron N, Nevo N, Lecourt S, Guerin CL, Renard JM, Gaussem P, Angles-Cano E, Boulanger CM, Israel-Biet D, Smadja DM. Endothelial Microparticles are Associated to Pathogenesis of Idiopathic Pulmonary Fibrosis. Stem Cell Rev. 2018 Apr;14(2):223-235. IF: 3.111 (Q2).

d’Audigier C, Susen S, Blandinieres A, Mattot V, Saubamea B, Rossi E, Nevo N, Lecourt S, Guerin CL, Dizier B, Gendron N, Caetano B, Gaussem P, Soncin F, Smadja DM. Egfl7 Represses the Vasculogenic Potential of Human Endothelial Progenitor Cells. Stem Cell Rev. 2018 Feb;14(1):82-91. IF: 3.111 (Q2).

Ruiz-Llorente L, Gallardo-Vara E, Rossi E, Smadja DM, Botella LM, Bernabeu C. Endoglin and alk1 as therapeutic targets for hereditary hemorrhagic telangiectasia. Expert Opin Ther Targets. 2017 Oct;21(10):933-947. IF: 4.9 (Q1)

Guerin CL, Rossi E, Cras A, Silvestre JS, Smadja DM. Human very small embryonic-like cells support vascular maturation and therapeutic revascularization induced by endothelial progenitor cells. Stem Cell Reviews and Reports 2017 Mar 16. IF: 3.111 (Q2).

Smadja DM, Levy M, Huang L, Rossi E, Blandinières A, Israel-Biet D, Gaussem P, Bischoff J. Treprostinil indirectly regulates endothelial colony forming cell angiogenic properties by increasing vegf-a produced by mesenchymal stem cells. Thrombosis and Haemostasis 2015 Jun 11;114(4). IF: 5.760 (Q1).

D’Audigier C, Cochain C, Rossi E, Guérin CL, Bièche I, Blandinières A, Marsac B , Silvestre JS, Gaussem P, Smadja DM. Thrombin receptor PAR-1 activation on endothelial progenitor cells enhances chemotaxis associated gene expression and leukocytes recruitment by a COX-2 dependent mechanism. Angiogenesis 2015 Jul;18(3):347-59. IF: 4.876 (Q1).

Rossi E, Lopez-Novoa JM, Bernabeu C. Endoglin involvement in integrin-mediated cell adhesion as a putative pathogenic mechanism in hereditary hemorrhagic Telangectasia type1 (HHT1). Frontiers in Genetics 2015; volume 5, article 457, 1-5. doi: 10.3389/fgene.2014.00457.

Bignotti E, Tassi RA, Calza S, Ravaggi A, Rossi E, Donzelli C, Todeschini P, Romani C, Bandiera E, Zanotti L, Tognon G, Sartori E, Pecorelli S, Santin AD. Secretoglobin expression analysis in epithelial ovarian cancer: lipophilin B gene upregulation is associated with better prognosis in ovarian carcinoma patients. Journal of Translational Medicine 2013 (2);11:162. doi:10.1186/1479-587, 2013. IF: 3.569 (Q2).

Rossi E, Gilsanz A, Langa C, Blanco FJ, Ayllon J, Villar E; Botella LM, Cabañas C, Shaw M, Bernabeu C. Characterization of chicken endoglin, a member of the zona pellucida family of proteins, and its tissue expression. Gene 2012 491(1):31-9. IF: 2.266 (Q3).

Villanacci V, Bassotti G, Salemme M, Rossi E. Influence of genetics on tumoral pathologies: The example of the adenocarcinoma arising in Barrett’s Esophagus. Rev Esp Enferm Dig 2012; 104(11): 592-602. IF: 1.548 (Q4).

Rossi E, Villanacci V, Danesino C, Donato F, Nascimbeni R, Bassotti G. Epidermal growth factor receptor overexpression/amplification in adenocarcinomas arising in the gastrointestinal tract. Rev Esp Enferm Dig 2011; 103(12): 632-639. IF: 1.548 (Q4).

Rossi E, Boeri L, Morbini P, Pagella F, Colombo A, Matti E, Olivieri C, Villanacci V, Minelli A, E. Buscarini, Canzonieri C, Danesino C. Immunohistochemical analysis of a merkeloma observed in a patient affected by hereditary Hemorragic Telangectasia. BMJ Case Report 2010; 2010. pii:bcr09.2009.2251.

Rossi E, Villanacci V, Bassotti G, Donato F, Grisanti S, Festa A, Cengia G, Cestari R. TOPOIIα and HER-2/neu overexpression/amplification in Barrett’s esophagus, dysplasia and adenocarcinoma. Histopathology 2010; 57(1):81-89. IF: 4.131 (Q1)